5 Key Takeaways

• 1

  Radiation retinopathy is the leading cause of vision loss after plaque brachytherapy for choroidal melanoma.

• 2

  Emerging strategies focus on preventing radiation retinopathy through reduced radiation doses and custom plaque designs.

• 3

  Investigational therapies like darovasertib and belzupacap sarotalocan aim to shrink tumors or destroy them without radiation.

• 4

  Prophylactic treatments with anti-VEGF injections may delay or prevent radiation retinopathy in patients post-radiation.

• 5

  A randomized trial is underway to evaluate early intervention strategies for preventing vision loss due to radiation retinopathy.