Objective:

To evaluate the effectiveness of ablation therapy and anti-VEGF injections in treating small uveal melanoma while avoiding radiation-related damage.

Key Findings:

• All patients achieved tumor control without radiation therapy.
• Average visual acuity improved from 20/63 at baseline to 20/32 at the study's end.
• 85% of patients maintained vision better than 20/40, suitable for reading/driving.

Interpretation:

The study demonstrates that ablation therapy combined with anti-VEGF injections can effectively manage small uveal melanoma while preserving vision and avoiding radiation-related complications.

Limitations:

• The study focused only on small uveal melanoma, limiting generalizability to other types.
• Long-term effects beyond the 5-year follow-up were not assessed.

Conclusion:

Ablation therapy and anti-VEGF treatment provide a viable alternative to radiation for managing small uveal melanoma, with significant improvements in visual acuity and tumor control.