Objective:

To evaluate the association between systemic statin use and the risk of proliferative vitreoretinopathy (PVR) and complex reoperation after retinal detachment (RD) repair.

Approach:

• Study Design: A retrospective study using the TriNetX network to identify patients with dyslipidemia who underwent primary RD repair, with 1:1 propensity score matching.
• Patient Cohorts: Included 9,978 patients: 4,989 statin users and 4,989 untreated dyslipidemic controls.
• Statin Use Criteria: Statin users had received therapy at least within a year prior to the index repair.

Key Findings:

• Statin use was associated with a 25% lower 1-year risk of PVR (3.8% in statin users vs. 4.7% in controls, P=.003).
• Complex RD reoperation rates were 8.2% in statin users compared to 9.1% in controls (P=.018).
• High-intensity statin use was linked to lower PVR risk (P=.031), while medium or low-intensity therapy was not.
• Lipophilic statins were associated with lower PVR risk (P=.011), whereas hydrophilic statins were not.
• Atorvastatin and simvastatin were associated with lower PVR risk, while rosuvastatin was not.

Limitations:

• The study is retrospective and cannot establish causation.
• The total duration of statin use prior to surgery was not available.

Sources:

• Retina Society Meeting