Home OCT and Modeling May Reduce Trial Sizes

Home OCT with PK/PD modeling achieved the same power as traditional biweekly, on-site monitoring with only 33 to 35 patients per arm

By: Sarah Fackler, managing editor, Optometric Management

Retinal Physician November 18, 2025 Vol 22, Issue November/December 2025

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Home OCT combined with PK/PD modeling can reduce sample size requirements in ophthalmology trials by 20% to 40% while maintaining statistical power.
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Traditional biweekly, on-site monitoring requires 41 to 54 patients per arm, whereas home OCT needs only 33 to 35 patients per arm.
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The study utilized a population PK/PD model to describe central subfield thickness dynamics following anti-VEGF therapy in neovascular age-related macular degeneration.
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High-frequency, patient-operated OCT data can improve endpoint precision and reduce recruitment needs in early ophthalmology trials.
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Future research should validate this approach in broader populations and assess factors affecting adherence and data quality.

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